Ultraminiaturized Microfluidic Electrochemical Surface‐Enhanced Raman Scattering Chip for Analysis of Neurotransmitters Fabricated by Ship‐in‐a‐Bottle Integration
نویسندگان
چکیده
Electrochemical surface-enhanced Raman scattering (EC-SERS) is a promising technique for the diagnosis of trace amounts neurotransmitters, because it can elucidate neurotransmitters’ behavior on electrodes to deduce their functions in human body. However, current EC-SERS devices need several tens milliliters analyte solution collect enough signal analysis. Miniaturization crucial early disease and point-of-care testing. Herein, new type sensor based 3D microfluidic chips analysis neurotransmitters ultrasmall volumes proposed. The chip fabricated by ship-in-a-bottle hybrid laser processing. working electrode modified using silver/zinc oxide materials, enabling formation unique “candy apple” structure. To assess chips, ascorbic acid analyzed ingenious its redox reaction spectroscopy. Significantly, sub-10 μL volume sufficient analysis, which orders smaller than requirements devices. unprecedented integration be used portable smart analyzers next-generation biomedicines catalysts.
منابع مشابه
Surface-enhanced Raman scattering microchip fabricated by femtosecond laser.
We report a surface-enhanced Raman scattering (SERS) microchip that is capable of measuring SERS signals of liquid samples with high sensitivity. The microdevice is an integration of a silicon-based SERS substrate, a multimode optical fiber (MMF), and a microchannel embedded in the photosensitive glass fabricated by the femtosecond laser followed by thermal treatment, wet etching, and annealing...
متن کاملSheath-Flow Microfluidic Approach for Combined Surface Enhanced Raman Scattering and Electrochemical Detection
The combination of hydrodynamic focusing with embedded capillaries in a microfluidic device is shown to enable both surface enhanced Raman scattering (SERS) and electrochemical characterization of analytes at nanomolar concentrations in flow. The approach utilizes a versatile polystyrene device that contains an encapsulated microelectrode and fluidic tubing, which is shown to enable straightfor...
متن کاملElectrochemical Hybrid Bio-sensors for Neurotransmitters Analysis
Abstrac t Biosensors are devices that detect and transmit information regarding a physiological change or the presence of various chemical or biological materials in a given environment. A new concept of electrochemical biosensors, directly related to the biological redox processes at the cellular and subcellular level, is proposed for testing microfluidic probes, in order to investigate and tr...
متن کاملCapillary-driven surface-enhanced Raman scattering (SERS)-based microfluidic chip for abrin detection
Herein, we firstly demonstrate the design and the proof-of-concept use of a capillary-driven surface-enhanced Raman scattering (SERS)-based microfluidic chip for abrin detection. The micropillar array substrate was etched and coated with a gold film by microelectromechanical systems (MEMS) process to integrate into a lateral flow test strip. The detection of abrin solutions of various concentra...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Small science
سال: 2023
ISSN: ['2688-4046']
DOI: https://doi.org/10.1002/smsc.202200093